Simon Elsässer

Publications

• Dual Bioorthogonal Labeling of the Amyloid-β Protein Precursor Facilitates Simultaneous Visualization of the Protein and Its Cleavage Products
• Quantitative Multiplexed ChIP Reveals Global Alterations that Shape Promoter Bivalency in Ground State Embryonic Stem Cells
• Genome-wide mapping of G-quadruplex structures with CUT&Tag
• Efficient multisite unnatural amino acid incorporation in mammalian cells via optimized pyrrolysyl tRNA synthetase/tRNA expression and engineered eRF1
• Anti-apoptotic Bcl-2 fails to form efficient complexes with pro-apoptotic Bak to protect from Celecoxib-induced apoptosis
• A common structural theme in histone chaperones mimics interhistone contacts
• Distinct transcription kinetics of pluripotent cell states
• Photoactivation of Mutant Isocitrate Dehydrogenase 2 Reveals Rapid Cancer-Associated Metabolic and Epigenetic Changes
• Generation of stable amber suppression cell lines
• minute: A MINUTE-ChIP data analysis workflow
• MINUTE ChIP v1
• Evolution of epigenetic chromatin states.
• Network analyses identify liver-specific targets for treating liver diseases.
• Elsässer et al. reply.
• Genetic code expansion in stable cell lines enables encoded chromatin modification.
• Towards policies that capture the expected value of biomolecular diversity for drug discovery, human health, and well-being
• Dual stop codon suppression in mammalian cells with genomically integrated genetic code expansion machinery
• Sirtuin-1 sensitive lysine-136 acetylation drives phase separation and pathological aggregation of TDP-43
• Revisiting sORFs: overcoming challenges to identify and characterize functional microproteins
• A large-scale sORF screen identifies putative microproteins and provides insights into their interaction partners, localisation and function
• Multianalyte serology in home-sampled blood enables an unbiased assessment of the immune response against SARS-CoV-2
• An embryonic stem cell-specific heterochromatin state promotes core histone exchange in the absence of DNA accessibility
• Histone H3.3 is required for endogenous retroviral element silencing in embryonic stem cells.
• Critical Role of Histone Turnover in Neuronal Transcription and Plasticity.
• Hira-dependent histone H3.3 deposition facilitates prc2 recruitment at developmental loci in ES cells
• Differential effects of anti-apoptotic Bcl-2 family members Mcl-1, Bcl-2, and Bcl-xL on Celecoxib-induced apoptosis
• DAXX envelops a histone H3.3-H4 dimer for H3.3-specific recognition
• HIRA and Daxx constitute two independent histone H3.3-containing predeposition complexes
• Phosphorylation of histone H3 Ser10 establishes a hierarchy for subsequent intramolecular modification events
• Towards a mechanism for histone chaperones
• New epigenetic drivers of cancers
• Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres
• Distinct Factors Control Histone Variant H3.3 Localization at Specific Genomic Regions
• Genetic encoding of photocaged cysteine allows photoactivation of TEV protease in live mammalian cells
• Proteome labeling and protein identification in specific tissues and at specific developmental stages in an animal
• DAXX co-folds with H3.3/H4 using high local stability conferred by the H3.3 variant recognition residues
• Evochromo: Towards a synthesis of chromatin biology and evolution
• Biodiversity, drug discovery, and the future of global health: Introducing the biodiversity to biomedicine consortium, a call to action
• Methanomethylophilus alvus Mx1201 provides basis for mutual orthogonal pyrrolysyl tRNA/aminoacyl-tRNA synthetase pairs in mammalian cells
• Methanomethylophilus alvus Mx1201 Provides Basis for Mutual Orthogonal Pyrrolysyl tRNA/Aminoacyl-tRNA Synthetase Pairs in Mammalian Cells
• Quantitative multiplexed ChIP reveals global alterations that shape promoter bivalency in ground state embryonic stem cells
• An embryonic stem cell-specific heterochromatin state allows core histone exchange in the absence of DNA accessibility
• Sirtuin-1 Sensitive Lysine-136 Acetylation Drives Phase Separation and Pathological Aggregation of TDP-43
• A translational multiplex serology approach to profile the prevalence of anti-SARS-CoV-2 antibodies in home-sampled blood
• Correction to: Towards policies that capture the expected value of biomolecular diversity for drug discovery, human health, and well-being
• Universal Single-Residue Terminal Labels for Fluorescent Live Cell Imaging of Microproteins
• Genome-wide mapping of G-quadruplex structures with CUT&Tag
• Newly synthesized RNA Sequencing Characterizes Transcription Dynamics in Three Pluripotent States
• Engineered human induced pluripotent cells enable genetic code expansion in brain organoids
• Polycomb Repressive Complex 2 shields naïve human pluripotent cells from trophectoderm differentiation
• New functions for an old variant: No substitute for histone H3.3
• Importance of Bak for celecoxib-induced apoptosis
• In situ observation of protein phosphorylation by high-resolution NMR spectroscopy
• Multiplexed chromatin immunoprecipitation sequencing for quantitative study of histone modifications and chromatin factors
• Pooled overexpression screening identifies PIPPI as a novel microprotein involved in the ER stress response