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Simon Elsässer

Publications

  • Dual Bioorthogonal Labeling of the Amyloid-β Protein Precursor Facilitates Simultaneous Visualization of the Protein and Its Cleavage Products
  • Quantitative Multiplexed ChIP Reveals Global Alterations that Shape Promoter Bivalency in Ground State Embryonic Stem Cells
  • Genome-wide mapping of G-quadruplex structures with CUT&Tag
  • Efficient multisite unnatural amino acid incorporation in mammalian cells via optimized pyrrolysyl tRNA synthetase/tRNA expression and engineered eRF1
  • Anti-apoptotic Bcl-2 fails to form efficient complexes with pro-apoptotic Bak to protect from Celecoxib-induced apoptosis
  • A common structural theme in histone chaperones mimics interhistone contacts
  • Distinct transcription kinetics of pluripotent cell states
  • Photoactivation of Mutant Isocitrate Dehydrogenase 2 Reveals Rapid Cancer-Associated Metabolic and Epigenetic Changes
  • Generation of stable amber suppression cell lines
  • minute: A MINUTE-ChIP data analysis workflow
  • MINUTE ChIP v1
  • Evolution of epigenetic chromatin states.
  • Network analyses identify liver-specific targets for treating liver diseases.
  • Elsässer et al. reply.
  • Genetic code expansion in stable cell lines enables encoded chromatin modification.
  • Towards policies that capture the expected value of biomolecular diversity for drug discovery, human health, and well-being
  • Dual stop codon suppression in mammalian cells with genomically integrated genetic code expansion machinery
  • Sirtuin-1 sensitive lysine-136 acetylation drives phase separation and pathological aggregation of TDP-43
  • Revisiting sORFs: overcoming challenges to identify and characterize functional microproteins
  • A large-scale sORF screen identifies putative microproteins and provides insights into their interaction partners, localisation and function
  • Multianalyte serology in home-sampled blood enables an unbiased assessment of the immune response against SARS-CoV-2
  • An embryonic stem cell-specific heterochromatin state promotes core histone exchange in the absence of DNA accessibility
  • Histone H3.3 is required for endogenous retroviral element silencing in embryonic stem cells.
  • Critical Role of Histone Turnover in Neuronal Transcription and Plasticity.
  • Hira-dependent histone H3.3 deposition facilitates prc2 recruitment at developmental loci in ES cells
  • Differential effects of anti-apoptotic Bcl-2 family members Mcl-1, Bcl-2, and Bcl-xL on Celecoxib-induced apoptosis
  • DAXX envelops a histone H3.3-H4 dimer for H3.3-specific recognition
  • HIRA and Daxx constitute two independent histone H3.3-containing predeposition complexes
  • Phosphorylation of histone H3 Ser10 establishes a hierarchy for subsequent intramolecular modification events
  • Towards a mechanism for histone chaperones
  • New epigenetic drivers of cancers
  • Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres
  • Distinct Factors Control Histone Variant H3.3 Localization at Specific Genomic Regions
  • Genetic encoding of photocaged cysteine allows photoactivation of TEV protease in live mammalian cells
  • Proteome labeling and protein identification in specific tissues and at specific developmental stages in an animal
  • DAXX co-folds with H3.3/H4 using high local stability conferred by the H3.3 variant recognition residues
  • Evochromo: Towards a synthesis of chromatin biology and evolution
  • Biodiversity, drug discovery, and the future of global health: Introducing the biodiversity to biomedicine consortium, a call to action
  • Methanomethylophilus alvus Mx1201 provides basis for mutual orthogonal pyrrolysyl tRNA/aminoacyl-tRNA synthetase pairs in mammalian cells
  • Methanomethylophilus alvus Mx1201 Provides Basis for Mutual Orthogonal Pyrrolysyl tRNA/Aminoacyl-tRNA Synthetase Pairs in Mammalian Cells
  • Quantitative multiplexed ChIP reveals global alterations that shape promoter bivalency in ground state embryonic stem cells
  • An embryonic stem cell-specific heterochromatin state allows core histone exchange in the absence of DNA accessibility
  • Sirtuin-1 Sensitive Lysine-136 Acetylation Drives Phase Separation and Pathological Aggregation of TDP-43
  • A translational multiplex serology approach to profile the prevalence of anti-SARS-CoV-2 antibodies in home-sampled blood
  • Correction to: Towards policies that capture the expected value of biomolecular diversity for drug discovery, human health, and well-being
  • Universal Single-Residue Terminal Labels for Fluorescent Live Cell Imaging of Microproteins
  • Genome-wide mapping of G-quadruplex structures with CUT&Tag
  • Newly synthesized RNA Sequencing Characterizes Transcription Dynamics in Three Pluripotent States
  • Engineered human induced pluripotent cells enable genetic code expansion in brain organoids
  • Polycomb Repressive Complex 2 shields naïve human pluripotent cells from trophectoderm differentiation
  • New functions for an old variant: No substitute for histone H3.3
  • Importance of Bak for celecoxib-induced apoptosis
  • In situ observation of protein phosphorylation by high-resolution NMR spectroscopy

Simon Elsässer's public data