Robert Månsson

Publications

• Chromatin Topology and the Regulation of Antigen Receptor Assembly
• Identification of Lin(-)Sca1(+)kit(+)CD34(+)Flt(3-) short-term hematopoietic stem cells capable of rapidly reconstituting and rescuing myeloablated transplant recipients
• A dose-dependent role for EBF1 in repressing non-B-cell-specific genes
• Ectopic expression of PAX5 promotes maintenance of biphenotypic myeloid progenitors coexpressing myeloid and B-cell lineage-associated genes
• Identification of Flt3(+) lympho-myeloid stem cells lacking erythro-megakaryocytic potential: A revised road map for adult blood lineage commitment
• Genomics based analysis of interactions between developing B-lymphocytes and stromal cells reveal complex interactions and two-way communication
• Gene expression analysis suggests that EBF-1 and PPAR gamma 2 induce adipogenesis of NIH-3T3 cells with similar efficiency and kinetics
• The Cxcl12, Periostin, and Ccl9 genes are direct targets for early B-cell factor in OP-9 stroma cells
• Single-cell analysis of the common lymphoid progenitor compartment reveals functional and molecular heterogeneity
• IL-7 mediates Ebf-1-dependent lineage restriction in early lymphoid progenitors
• Critical role of FLT3 ligand in IL-7 receptor-independent T lymphopoiesis and regulation of lymphoid-primed multipotent progenitors
• Positive intergenic feedback circuitry, involving EBF1 and FOXO1, orchestrates B-cell fate
• Predictive screening for regulators of conserved functional gene modules (gene batteries) in mammals
• Absence of a common founder mutation in patients with cooccurring myelodysplastic syndrome and plasma cell disorder
• High-throughput ChIPmentation: freely scalable, single day ChIPseq data generation from very low cell-numbers
• Bhlhe40 function in activated B and TFH cells restrains the GC reaction and prevents lymphomagenesis
• Global changes in the nuclear positioning of genes and intra- and interdomain genomic interactions that orchestrate B cell fate
• CCAAT/enhancer binding protein alpha (C/EBP alpha)-induced transdifferentiation of pre-B cells into macrophages involves no overt retrodifferentiation
• A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fate
• Interleukin-7-induced Stat-5 Acts in Synergy with Flt-3 Signaling to Stimulate Expansion of Hematopoietic Progenitor Cells
• The transcription factors E2A and HEB act in concert to induce the expression of FOXO1 in the common lymphoid progenitor
• The molecular signature of MDS stem cells supports a stem-cell origin of 5q - myelodysplastic syndromes
• Cytokines regulate postnatal hematopoietic stem cell expansion: opposing roles of thrombopoietin and LNK
• Hematopoietic Stem Cell Expansion Precedes the Generation of Committed Myeloid Leukemia-initiating Cells in C/EBP alpha Mutant AML
• B-lineage commitment prior to surface expression of B220 and CD19 on hematopoietic progenitor cells
• E2A proteins promote development of lymphoid-primed multipotent progenitors
• EBF1 is essential for B-Lineage priming and establishment of a transcription factor network in common lymphoid progenitors
• Exit of pediatric pre-B acute lymphoblastic leukaemia cells from the bone marrow to the peripheral blood is not associated with cell maturation or alterations in gene expression
• Modeling of C/EBP alpha mutant acute myeloid leukemia reveals a common expression signature of committed myeloid leukemia-initiating cells
• Molecular profiling reveals distinct functional attributes of CD1d-restricted natural killer (NK) T cell subsets
• Critical role of thrombopoietin in maintaining adult quiescent hematopoietic stem cells
• Elucidation of the phenotypic, functional, and molecular topography of a myeloerythroid progenitor cell hierarchy
• Molecular evidence for hierarchical transcriptional lineage priming in fetal and adult stem cells and multipotent progenitors
• The CD53 and CEACAM-1 genes are genetic targets for early B cell factor
• Pearson correlation analysis of microarray data allows for the identification of genetic targets for early B-cell factor
• RNA analysis of B cell lines arrested at defined stages of differentiation allows for an approximation of gene expression patterns during B cell development
• Splice-correction strategies for treatment of X-linked agammaglobulinemia.
• Targets for Ibrutinib Beyond B Cell Malignancies.
• The chromatin remodeler Brg1 activates enhancer repertoires to establish B cell identity and modulate cell growth.
• Loss of Murine FOXO3 in Cells of the Myeloid Lineage Enhances Myelopoiesis but Protects from K/BxN-Serum Transfer-Induced Arthritis.
• Ebf1 heterozygosity results in increased DNA damage in pro-B cells and their synergistic transformation by Pax5 haploinsufficiency.
• Variants in ELL2 influencing immunoglobulin levels associate with multiple myeloma.
• Splice-correcting oligonucleotides restore BTK function in X-linked agammaglobulinemia model.
• Aging is associated with functional and molecular changes in distinct hematopoietic stem cell subsets