PA
Per Andrén
Professor (Biological sciences; Biomedical and clinical sciences; Chemical sciences; Health sciences)
Uppsala University, Uppsala, Sweden
Publications
- Region-Specific and Age-Dependent Multitarget Effects of Acetylcholinesterase Inhibitor Tacrine on Comprehensive Neurotransmitter Systems
- Erratum to: Association of chromosome 19 to lung cancer genotypes and phenotypes
- Direct imaging of elemental distributions in tissue sections by laser ablation mass spectrometry
- Uncovering the regional localization of inhaled salmeterol retention in the lung
- Yale School of Public Health Symposium on tissue imaging mass spectrometry: illuminating phenotypic heterogeneity and drug disposition at the molecular level
- An introduction to MS imaging in drug discovery and development
- Future technology insight: mass spectrometry imaging as a tool in drug research and development
- msIQuant - Quantitation Software for Mass Spectrometry Imaging Enabling Fast Access, Visualization, and Analysis of Large Data Sets
- Aurora kinase inhibitor nanoparticles target tumors with favorable therapeutic index in vivo
- Association of chromosome 19 to lung cancer genotypes and phenotypes
- Editorial and Review: 29th ASMS Sanibel Conference on Mass Spectrometry-Peptidomics: Bridging the Gap between Proteomics and Metabolomics by MS
- Mass spectrometry imaging identifies palmitoylcarnitine as an immunological mediator during Salmonella Typhimurium infection
- Asymmetry of the endogenous opioid system in the human anterior cingulate: a putative molecular basis for lateralization of emotions and pain
- Design, synthesis and in vitro biological evaluation of oligopeptides targeting E. coli type I signal peptidase (LepB)
- Exemplifying the Screening Power of Mass Spectrometry Imaging over Label-Based Technologies for Simultaneous Monitoring of Drug and Metabolite Distributions in Tissue Sections
- Striatal Tyrosine Hydroxylase Is Stimulated via TAAR1 by 3-Iodothyronamine, But Not by Tyramine or β-Phenylethylamine
- How Does the Sweet Violet (Viola odorata L.) Fight Pathogens and Pests - Cyclotides as a Comprehensive Plant Host Defense System
- Brain Tissue Sample Stabilization and Extraction Strategies for Neuropeptidomics
- Comprehensive mapping of neurotransmitter networks by MALDI-MS imaging
- A mass spectrometry imaging approach for investigating how drug-drug interactions influence drug blood-brain barrier permeability
- Detection of a High-Turnover Serotonin Circuit in the Mouse Brain Using Mass Spectrometry Imaging
- Efficacy of EBL-1003 (apramycin) against Acinetobacter baumannii lung infections in mice
- Revealing the Regional Localization and Differential Lung Retention of Inhaled Compounds by Mass Spectrometry Imaging
- Deficits in Motor Performance, Neurotransmitters and Synaptic Plasticity in Elderly and Experimental Parkinsonian Mice Lacking GPR37
- Simultaneous mass spectrometry imaging of multiple neuropeptides in the brain and alterations induced by experimental parkinsonism and L-DOPA therapy
- Non-dopaminergic Alterations in Depression-Like FSL Rats in Experimental Parkinsonism and L-DOPA Responses
- Mass spectrometry imaging identifies abnormally elevated brain l-DOPA levels and extrastriatal monoaminergic dysregulation in l-DOPA-induced dyskinesia
- µ Opioid Receptor Agonism for L-DOPA-Induced Dyskinesia in Parkinson's Disease
- Well-Plate μFASP for Proteomic Analysis of Single Pancreatic Islets
- Electrochemically Etched Tapered-Tip Stainless-Steel Electrospray-Ionization Emitters for Capillary Electrophoresis–Mass Spectrometry
- Mass Spectrometry Imaging proves differential absorption profiles of well-characterised permeability markers along the crypt-villus axis
- Neuropharmacokinetic visualization of regional and subregional unbound antipsychotic drug transport across the blood–brain barrier
- Enantioselective CE–MS analysis of ketamine metabolites in urine
- On-Tissue Chemical Derivatization for Comprehensive Mapping of Brain Carboxyl and Aldehyde Metabolites by MALDI–MS Imaging
- GABA, glucose and insulin orchestrate CD4+T cells effector functions
- Basal ganglia neuropeptides show abnormal processing associated with L-DOPA-induced dyskinesia
- Advances in spatial mass spectrometry enable in-depth neuropharmacodynamics
- Peptide ion channel toxins from the bootlace worm, the longest animal on Earth
- Zero-Degree Celsius Capillary Electrophoresis Electrospray Ionization for Hydrogen Exchange Mass Spectrometry
- The Influence of Plant Stress Hormones and Biotic Elicitors on Cyclotide Production in Viola uliginosa Cell Suspension Cultures
- A Space Efficient Direct Access Data Compression Approach for Mass Spectrometry Imaging
- Quantitation of Endogenous Metabolites in Mouse Tumors Using Mass-Spectrometry Imaging
- Molecular imaging identifies age-related attenuation of acetylcholine in retrosplenial cortex in response to acetylcholinesterase inhibition
- α-synuclein−lipoprotein interactions and elevated ApoE level in cerebrospinal fluid from Parkinson's disease patients
- Simultaneous imaging of multiple neurotransmitters and neuroactive substances in the brain by desorption electrospray ionization mass spectrometry
- Bromopyrylium Derivatization Facilitates Identification by Mass Spectrometry Imaging of Monoamine Neurotransmitters and Small Molecule Neuroactive Compounds
- Cross-validated Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging Quantitation Protocol for a Pharmaceutical Drug and Its Drug-Target Effects in the Brain Using Time-of-Flight and Fourier Transform Ion Cyclotron Resonance Analyzers
- Integration of Mass Spectrometry Imaging and Machine Learning Visualizes Region-Specific Age-Induced and Drug-Target Metabolic Perturbations in the Brain
- Spatial visualization of comprehensive brain neurotransmitter systems and neuroactive substances by selective in situ chemical derivatization mass spectrometry imaging
- Wide-Ranging Effects on the Brain Proteome in a Transgenic Mouse Model of Alzheimer’s Disease Following Treatment with a Brain-Targeting Somatostatin Peptide
- Pyrylium Salts as Reactive Matrices for MALDI-MS Imaging of Biologically Active Primary Amines
- Development and evaluation of normalization methods for label-free relative quantification of endogenous peptides
- Proteomics
- A quantitative peptidomic analysis of peptides related to the endogenous opioid and tachykinin systems in nucleus accumbens of rats following naloxone-precipitated morphine withdrawal
- Coupling surface plasmon resonance to mass spectrometry to discover novel protein-protein interactions
- Heat stabilization of the tissue proteome: a new technology for improved proteomics
- MALDI Imaging and Profiling Mass Spectrometry in Neuroproteomics
- In vitro neurotoxicity of PBDE-99: immediate and concentration-dependent effects on protein expression in cerebral cortex cells
- Fine mapping the spatial distribution and concentration of unlabeled drugs within tissue micro-compartments using imaging mass spectrometry
- Striatal alterations of secretogranin-1, somatostatin, prodynorphin, and cholecystokinin peptides in an experimental mouse model of Parkinson disease
- Neuropeptidomic analysis of the embryonic Japanese quail diencephalon
- In vivo investigation of brain and systemic ketobemidone metabolism
- Essential tactics of tissue preparation and matrix nano-spotting for successful compound imaging mass spectrometry
- Proteomic profiling of the Baltic Sea cyanobacterium Nodularia spumigena strain AV1 during ammonium supplementation
- The transition of the European Proteomics Association into the future
- Qualitative and quantitative MALDI imaging of the positron emission tomography ligands raclopride (a D2 dopamine antagonist) and SCH 23390 (a D1 dopamine antagonist) in rat brain tissue sections using a solvent-free dry matrix application method
- Neuropeptide profiling of the bovine hypothalamus: thermal stabilization is an effective tool in inhibiting post-mortem degradation
- Identification of protein-protein interactions by surface plasmon resonance followed by mass spectrometry
- Caveolin-1 interacts with alpha-synuclein and mediates toxic actions of cellular alpha-synuclein overexpression
- Conductive carbon tape used for support and mounting of both whole animal and fragile heat-treated tissue sections for MALDI MS imaging and quantitation
- Novel mass spectrometry imaging software assisting labeled normalization and quantitation of drugs and neuropeptides directly in tissue sections
- In situ mass spectrometry imaging and ex vivo characterization of renal crystalline deposits induced in multiple preclinical drug toxicology studies
- Imaging mass spectrometry: a user's guide to a new technique for biological and biomedical research. Preface
- Going forward: Increasing the accessibility of imaging mass spectrometry
- Neuropeptidomics of mouse hypothalamus after imipramine treatment reveal somatostatin as a potential mediator of antidepressant effects
- Extensive characterization of Tupaia belangeri neuropeptidome using an integrated mass spectrometric approach
- Abnormal structure-specific peptide transmission and processing in a primate model of Parkinson's disease and l-DOPA-induced dyskinesia
- Identification of best indicators of peptide-spectrum match using a permutation resampling approach
- Developing new methods to answer old and new questions in neurodegenerative diseases: 21(st) Workshop of the HUPO Brain Proteome Project (HBPP) 23-24 January 2014, Honolulu, Hawaii
- Mass spectrometry imaging, an emerging technology in neuropsychopharmacology
- Mass spectrometry imaging of cassette-dosed drugs for higher throughput pharmacokinetic and biodistribution analysis
- Discussion point: reporting guidelines for mass spectrometry imaging
- Neurotoxin-induced neuropeptide perturbations in striatum of neonatal rats
- High identification rates of endogenous neuropeptides from mouse brain
- Deuterated matrix-assisted laser desorption ionization matrix uncovers masked mass spectrometry imaging signals of small molecules
- Chronic nicotine treatment impacts the regulation of opioid and non-opioid peptides in the rat dorsal striatum
- Developments in biobanking workflow standardization providing sample integrity and stability
- Controlled-pH tissue cleanup protocol for signal enhancement of small molecule drugs analyzed by MALDI-MS imaging
- Direct targeted quantitative molecular imaging of neurotransmitters in brain tissue sections
- Investigating nephrotoxicity of polymyxin derivatives by mapping renal distribution using mass spectrometry imaging
- Mass spectrometry imaging in drug development
- Use of ENCODE Resources to Characterize Novel Proteoforms and Missing Proteins in the Human Proteome
- Analytical utility of small neutral losses from reduced species in electron capture dissociation studied using SwedECD database
- Evaluation of database search programs for accurate detection of neuropeptides in tandem mass spectrometry experiments
- The significance of ambient-temperature on pharmaceutical and endogenous compound abundance and distribution in tissues sections when analyzed by matrix-assisted laser desorption/ionization mass spectrometry imaging
- Impact of temperature dependent sampling procedures in proteomics and peptidomics--a characterization of the liver and pancreas post mortem degradome
- Distribution, level, pharmacology, regulation, and signaling of 5-HT6 receptors in rats and marmosets with special reference to an experimental model of parkinsonism
- High speed data processing for imaging MS-based molecular histology using graphical processing units
- Accurate assignment of significance to neuropeptide identifications using Monte Carlo k-permuted decoy databases
- Chromosome 19 annotations with disease speciation: a first report from the Global Research Consortium
- High frequency oral movements induced by long-term administration of amperozide but not FG5803 in rats
- In vitro metabolism of LVV-hemorphin-7 in human plasma studied by reversed-phase high-performance liquid chromatography and micro-electrospray mass spectrometry
- Isolation of haemorphin-related peptides from filter membranes collected in connection with haemofiltration of human subjects
- Coadministration of (-)-OSU6162 with l-DOPA normalizes preproenkephalin mRNA expression in the sensorimotor striatum of primates with unilateral 6-OHDA lesions
- Simultaneous analysis of endogenous neurotransmitters and neuropeptides in brain tissue using capillary electrophoresis--microelectrospray-tandem mass spectrometry
- Determination of extracellular release of neurotensin in discrete rat brain regions utilizing in vivo microdialysis/electrospray mass spectrometry
- Motor effects of (-)-OSU6162 in primates with unilateral 6-hydroxydopamine lesions
- Identification of glucuronide conjugates of ketobemidone and its phase I metabolites in human urine utilizing accurate mass and tandem time-of-flight mass spectrometry
- Tardive dyskinesia model in the common marmoset
- The significance of biochemical and molecular sample integrity in brain proteomics and peptidomics: stathmin 2-20 and peptides as sample quality indicators
- Neuropeptidomics: MS applied to the discovery of novel peptides from the brain
- Altered extracellular striatal in vivo biotransformation of the opioid neuropeptide dynorphin A(1-17) in the unilateral 6-OHDA rat model of Parkinson's disease
- Electrokinetic-driven microfluidic system in poly(dimethylsiloxane) for mass spectrometry detection integrating sample injection, capillary electrophoresis, and electrospray emitter on-chip
- Increased levels of ubiquitin in the 6-OHDA-lesioned striatum of rats
- SwePep, a database designed for endogenous peptides and mass spectrometry
- Normalization and expression changes in predefined sets of proteins using 2D gel electrophoresis: a proteomic study of L-DOPA induced dyskinesia in an animal model of Parkinson's disease using DIGE
- Sample pretreatment on a microchip with an integrated electrospray emitter
- Decreased striatal levels of PEP-19 following MPTP lesion in the mouse
- Repeated l-DOPA treatment increases c-fos and BDNF mRNAs in the subthalamic nucleus in the 6-OHDA rat model of Parkinson's disease
- Neuropeptidomics strategies for specific and sensitive identification of endogenous peptides
- An automated method for scanning LC-MS data sets for significant peptides and proteins, including quantitative profiling and interactive confirmation
- SwedCAD, a database of annotated high-mass accuracy MS/MS spectra of tryptic peptides
- In vivo processing of LVV-hemorphin-7 in rat brain and blood utilizing microdialysis combined with electrospray mass spectrometry
- Peptidomics-based discovery of novel neuropeptides
- Capillary electrophoresis coupled to mass spectrometry from a polymer modified poly(dimethylsiloxane) microchip with an integrated graphite electrospray tip
- In vitro imaging techniques in neurodegenerative diseases
- Poly(dimethylsiloxane)-based microchip for two-dimensional solid-phase extraction-capillary electrophoresis with an integrated electrospray emitter tip
- Increased striatal mRNA and protein levels of the immunophilin FKBP-12 in experimental Parkinson's disease and identification of FKBP-12-binding proteins
- Neurokinin B/NK3 receptors exert feedback inhibition on L-DOPA actions in the 6-OHDA lesion rat model of Parkinson's disease
- Evidence for a role of the 5-HT1B receptor and its adaptor protein, p11, in L-DOPA treatment of an animal model of Parkinsonism
- Striatal proteomic analysis suggests that first L-dopa dose equates to chronic exposure
- Method development for identification of ketobemidone metabolites in microdialysate samples by coupled-column capillary liquid chromatography-tandem mass spectrometry
- Behavioral and neurochemical consequences of ibotenic acid lesion in the subthalamic nucleus of the common marmoset
- (-)-OSU 6162 inhibits levodopa-induced dyskinesias in a monkey model of Parkinson's disease
- Reversed-phase high-performance liquid chromatography combined with tandem mass spectrometry in studies of a substance P-converting enzyme from human cerebrospinal fluid
- Purification and characterization of substance P endopeptidase activities in the rat spinal cord
- Blood-brain barrier penetration of 3-aminopropyl-n-butylphosphinic acid (CGP 36742) in rat brain by microdialysis/mass spectrometry
- Combining solid-phase preconcentration, capillary electrophoresis and off-line matrix-assisted laser desorption/ionization mass spectrometry: intracerebral metabolic processing of peptide E in vivo
- L-DOPA produces strong induction of c-fos messenger RNA in dopamine-denervated cortical and striatal areas of the common marmoset
- Naloxone reduces levodopa-induced dyskinesias and apomorphine-induced rotations in primate models of parkinsonism
- alpha-methylene ordering of acyl chains differs in glucolipids and phosphatidylglycerol from Acholeplasma laidlawii membranes: (2)H-NMR quadrupole splittings from individual lipids in mixed bilayers
- A neuroproteomic approach to targeting neuropeptides in the brain
- Acute and repeated treatment with L-DOPA increase c-jun expression in the 6-hydroxydopamine-lesioned forebrain of rats and common marmosets
- Motor effects of a dopamine stabilizer (GMC1111) in primate models of Parkinson and hemiparkinsonism
- Molecular profiling of experimental Parkinson's disease: direct analysis of peptides and proteins on brain tissue sections by MALDI mass spectrometry
- Neuropeptidomics: expanding proteomics downwards
- Exposure to brominated flame retardant PBDE-99 affects cytoskeletal protein expression in the neonatal mouse cerebral cortex
- Validation of endogenous peptide identifications using a database of tandem mass spectra
- Use of surface plasmon resonance coupled with mass spectrometry reveals an interaction between the voltage-gated sodium channel type X alpha-subunit and caveolin-1
- Changes on 5-HT2 receptor mRNAs in striatum and subthalamic nucleus in Parkinson's disease model
- Analysis of pethidine disposition in the pregnant rat by means of a physiological flow model
- Intranigral infusion of enkephalins elicits dyskinetic biting in rats
- Neurobiochemical changes in tardive dyskinesia
- Analysis of methadone disposition in the pregnant rat by means of a physiological flow model
- Chronic neuroleptics alter the effects of the D1 agonist SK&F 38393 and the D2 agonist LY171555 on oral movements in rats
- Methylazoxymethanol (MAM)-induced brain lesion and oral dyskinesia in rats
- Micro-Electrospray: Zeptomole/attomole per microliter sensitivity for peptides
- An animal model for coexisting tardive dyskinesia and tardive parkinsonism: a glutamate hypothesis for tardive dyskinesia
- Regional changes in 2-deoxyglucose uptake associated with neuroleptic-induced tardive dyskinesia in the Cebus monkey
- Characterization of neurotensin-like immunoreactivity in human cerebrospinal fluid by high-performance liquid chromatography combined with mass spectrometry
- Specific molecular mass detection of endogenously released neuropeptides using in vivo microdialysis/mass spectrometry
- Intranigral tachykinin NK3 receptor agonist elicits oral movements in rats
- Spontaneous chewing movements in rats during acute and chronic antipsychotic drug administration
- Chronic melperone administration does not enhance oral movements in rats
- Opposite effects of a D1 and a D2 agonist on oral movements in rats
- Characterization and application of animal models for tardive dyskinesia
- Modulation of oral movements by intranigral 5-hydroxytryptamine receptor agonists in the rat
- Neuropeptide changes in a primate model (Cebus apella) for tardive dyskinesia
- [What is the connection between Parkinson disease and tardive dyskinesia?]
- Spatial lipidomics reveals brain region-specific changes of sulfatides in an experimental MPTP Parkinson’s disease primate model
- Label-Free Quantitative Thermal Proteome Profiling Reveals Target Transcription Factors with Activities Modulated by MC3R Signaling
- Rapid Metabolic Profiling of 1 μL Crude Cerebrospinal Fluid by Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging Can Differentiate De Novo Parkinson’s Disease
- Hydrogen production by a fully de novo enzyme
- Regional Changes in Brain Biomolecular Markers in a Collagen-Induced Arthritis Rat Model
- Applying Spatial Metabolomics To Investigate Age- and Drug-Induced Neurochemical Changes
- Hydrazide-based reactive matrices for the sensitive detection of aldehydes and ketones by MALDI mass spectrometry imaging
- Spatial multiomic insights into acute cocaine exposure
- Enduring modulation of dorsal raphe nuclei regulates (R,S)-ketamine-mediated resilient stress-coping behavior
- Met-ID: An Open-Source Software for Comprehensive Annotation of Multiple On-Tissue Chemical Modifications in MALDI-MSI