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Timing chromosomal amplification events using patterns of somatic mutations in high hyperdiploid acute lymphoblastic leukemia

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posted on 2023-02-02, 07:05 authored by Eleanor Woodward, Minjun YangMinjun Yang, Larissa Helena Moura-Castro, Hilda van den Bos, Rebeqa GunnarssonRebeqa Gunnarsson, Linda Olsson Arvidsson, Diana C. J. Spierings, Anders Castor, Nicolas Duployez, Marketa Zaliova, Jan Zuna, Bertil Johansson, Floris Foijer, Kajsa Paulsson

This dataset included 22 patients with high hyperdiploid acute lymphoblastic leukemia (ALL) collected from the Division of Clinical Genetics, Lund University, Sweden. All samples were subjected to whole genome sequencing by the Illumina HiSeqX platform. Paired-end sequencing (2x150bp) was done to ~60x coverage for diagnostic samples and ~30x coverage for remission. The paired-end reads were aligned to the human reference genome GRCh37 (https://www.ncbi.nlm.nih.gov/assembly/GCF_000001405.25/) by the Burrows-Wheeler Aligner tool (version 0.7.17). Duplicate reads marking and local realignment were performed by GATK (version Somatic variants were identified by the GDC DNA-Seq analysis pipeline (Zhang et al.,2021). The data was stored in vcf format and the interpretation of the file is available at: https://docs.gdc.cancer.gov/Data/File_Formats/VCF_Format/. 


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Swedish Childhood Cancer Foundation(PR2018-0023, PR2020-0033, and TJ2020-0024)

Swedish Cancer Fund (19-0252-Pj)

Governmental funding of clinical research within the National Health Service (ALFSKANE-623431)

Gunnar Nilsson Cancer Foundation (GN-2020-9 -(190))

The Royal Physiographic Society of Lund



Lund University