The genomic landscape of relapsed infant and childhood KMT2A-rearranged acuteleukemia
dataset
posted on 2024-07-08, 14:09 authored by Mattias PilhedenMattias Pilheden, Anna Hagström Andersson, Louise Ahlgren, Helena Sturesson, Varsha Singh, Guangchun Song, Michael P. Walsh, Minjun Yang, Anders Castor, Cornelis Jan Pronk, Huanbin Zhao, Maud Maillard, Hanne Vibeke Marquart, Birgitte Lausen, Pauline Schneider, Gisela BarbanyGisela Barbany, Katja Pokrovskaja-Tamm, Jonas Abrahamsson, Olli Lohi, Linda Fogelstrand, Pablo Menendez, Rob Pieters, Jun J. Yang, Jinghui Zhang, Karin Lindkvist-Petersson, Ronald W. Stam, Jing MaThis dataset includes whole genome and whole exome sequencing of diagnostic, germline, and relapse samples of 21 infants and 12 children with relapsed ALL (n=21) or AML (n=12), and targeted deep sequencing of 258 samples taken during treatment for 30 infants or children with ALL or AML. All patients had an underlying rearrangement of the KMT2A gene
Whole genome and exome sequencing was performed using Illumina TruSeq Nano protocol. Targeted sequencing libraries was prepared using Nextera XT DNA Sample Preparation Kit (Illumina) and sequenced on the Illumina MiSeq.
Funding
PR2018-0027
CAN 2017/438
The molecular pathogenesis of KMT2A-rearranged leukemia from infancy to adulthood and the clinical impact of tumor heterogeneity
Swedish Research Council
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