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Reason: Sequencing was performed at BGI and the sequencing data is stored locally in our lab. We will deposit the WGS data to EGA-SE depository when it is completed.

Single base substitution mutational signatures in pediatric acute myeloid leukemia based on whole genome sequencing

posted on 2022-04-04, 12:15 authored by Rebeqa GunnarssonRebeqa Gunnarsson, Minjun YangMinjun Yang, Linda Olsson Arvidsson, andrea Biloglav, Mikael Behrendtz, Anders Castor, Kajsa Paulsson, Bertil Johansson
This dataset includes whole genome sequencing (WGS) data of 20 diagnostic, and 20 remission samples from 20 children/adolescents with acute myeloid leukemia (AML), treated at the Departments of Pediatrics at Lund and Linköping University Hospitals between 1994 and 2016. The median age of the patients was 8 years (range 0-17 years) and the female/male ratio was 1:1. DNA was extracted from diagnostic bone marrow (BM; n = 17)/peripheral blood (PB; n = 3) samples, remission BM (n = 15)/PB (n = 5), and from two BM relapses. Construction of libraries, using the TruSeq Nano DNA sample preparation kit (Illumina, San Diego, CA, USA) on 100 ng DNA, and massively parallel sequencing were performed by BGI Tech Solutions (Hong Kong). The WGS (Illumina HiSeqX) reached an average sequencing depth of 30-42x/sample (median 33x), with 2x 150 bp read length.


Swedish Cancer Society (20 0792 PjF)

Swedish Childhood Cancer Foundation (PR2018-0008 and TJ2020-0024)

Governmental Funding of Clinical Research within the National Health Service

Genetic and epigenetic studies of pediatric acute leukemia

Swedish Research Council

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Lund University

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