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Proteome profiling of home-sampled dried blood spots reveals proteins of SARS-CoV-2 infections

posted on 2024-03-19, 14:42 authored by Claudia Fredolini, Tea Dodig-CrnkovicTea Dodig-Crnkovic, Annika Bendes, Leo Dahl, Matilda Dale, Cecilia Mattsson, Cecilia Engel Thomas, Vincent Albrecht, Åsa Torinsson Naluai, Magnus Gisslen, Olof Beck, Niclas Roxhed, Jochen SchwenkJochen Schwenk

The report contains data on protein levels obtained from dried blood spot (DBS) samples.

The DBS originated from donors who provided self-sampling blood using a sampling kit (Capitainer AB). The studies were conducted in the general population in Stockholm and Gothenburg (Sweden) during the COVID-19 pandemic in the spring of 2020 and 2021:

  • Levels of circulating antibodies were determined in the 2021 study by multi-analyte serology using the Luminex platform. Serology data from the 2020 studies have been deposited in a previous submission. All data sets have been processed and normalized using a linear model described in the publication of the previous submission.
  • Levels of circulating proteins were determined by proximity extension assays using three Target96 panels from the Olink platform. The raw NPX data has been processed using AbsPQN, as described in the manuscript related to this submission.
  • Other data is provided in the manuscript.

Access to this individual-level human data can be granted for non-commercial validation purposes and upon reasonable request to the provided contact. A reasonable request should contain the following:

  1. Name of PI and host organization
  2. Contact details
  3. The scientific purpose of the data access request
  4. Commitment to inform when the data has been used in a publication
  5. Commitment not to host or share the data outside the requesting organization
  6. Statement of non-commercial use of data


SciLifeLab’s Pandemic Laboratory Preparedness program (VC-2022-0028)

VINNOVA - Sweden’s innovation agency (2020-04451)

Knut and Alice Wallenberg Foundation to Science for Life Laboratory (2020.0241)

Wallenberg AI, Autonomous Systems and Software Program (WASP) funded by the Knut and Alice Wallenberg Foundation

Erling Persson Family Foundation for the project “Future-proofing against COVID-19”

Knut and Alice Wallenberg Foundation to Science for Life Laboratory (2020.0182)



KTH Royal Institute of Technology

Access request email

SciLifeLab acknowledgement

  • Affinity Proteomics unit
  • Autoimmunity and Serology Profiling unit