Prevalent and persistent new-onset autoantibodies in mild to severe COVID-19

<p dir="ltr"><b>Note: The DOI of the related paper will be provided upon publication.</b></p><p dir="ltr">These datasets contain information on autoantibody and anti-SARS-CoV-2 IgG levels.</p><p dir="ltr">In this study, 478 healthcare workers and 48 patients were followed prospectively over 5 visits from May 2020 to Sept 2021. SARS-CoV-2 serology and autoantibodies were assessed using planar and bead-based arrays. Detected epitopes were validated in blood and cerebrospinal fluid from two independent cohorts of Neuro-COVID patients (n=25) and pre-pandemic healthy controls (n=29).</p><p dir="ltr">The datasets contain:</p><ul><li><b>SARS-CoV-2 serological profiles</b> measured in all samples (above) using 3-plex bead arrays. The data is reported as raw and normalized MFI (AU) and compound serostatus.</li><li><b>Proteome-wide autoantibody profiles</b> measured in 12 sample pools using planar arrays. The data is reported as median fluorescent intensity, in raw and normalized arbitrary units (MFI [AU]), and reactivity classification.</li><li><b>Targeted autoantibody profiles</b> measured in 478 healthcare workers and 48 patients across 5 time points using 363-plex bead arrays. The data is reported as raw and normalized MFI (AU), fold change (FC) across infection, and new-onset classification.</li><li><b>Peptide epitope mapping autoantibody profiles</b> measured in a 142 healthcare workers and COVID-19 patients across 2 time points, and all Neuro-COVID patients (n=25) and pre-pandemic healthy controls (n=29), using 93-plex bead arrays. The data is reported as raw and normalized MFI (AU), and fold change (FC) across infection.</li></ul><p dir="ltr">Source data is provided with the paper.</p><p dir="ltr">Access to this individual-level human data can be granted for <b>non-commercial</b><b> </b><b>v</b><b>alidation purposes</b> and upon reasonable request to the provided contact. A reasonable request should contain the following:</p><ol><li>Name of PI and host organization</li><li>Contact details</li><li>The scientific purpose of the data access request</li><li>Commitment to inform when the data has been used in a publication</li><li>Commitment not to host or share the data outside the requesting organization</li><li>Statement of non-commercial use of data</li></ol><p></p>