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Immunoglobulin M and immunoglobulin G repertoire sequencing data of two donors first infected with SARS-CoV-2 then vaccinated with mRNA-1273

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posted on 2023-03-17, 10:40 authored by Mark ChernyshevMark Chernyshev, Mrunal Sakharkar, Ruth I. Connor, Haley L. Dugan, Daniel J. Sheward, C. Garrett Rappazzo, Aron Stålmarck, Mattias M.N. Forsell, Peter F. Wright, Martin Corcoran, Ben Murrell, Laura M. Walker, Gunilla B. Karlsson Hedestam

Immunoglobulin M (IgM) and immunoglobulin G (IgG) repertoire sequencing libraries from two donors who were first infected by index SARS-CoV-2, then vaccinated by the mRNA-1273 vaccine. We acquired longitudinal peripheral blood mononuclear cells (PBMCs) samples from each respective donor as follows: 11 or 14 days post-infection (acute timepoint), 32 or 37 days post-infection (convalescent timepoint), 160 or 169 days post-infection (pre-vax timepoint), and 9 or 7 days post-vaccination (post-vax timepoint). Three IgM libraries were generated from each donor for the Acute timepoint, as well as one IgG library per timepoint per donor for a total of 6 IgM and 6 IgG Rep-seq libraries.

Funding

SciLifeLab National COVID-19 Research Program (C19VE:G:007)

Knut and Alice Wallenberg Foundation

Genetic basis for antibody diversity

Swedish Research Council

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Karolinska Institutet

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datacentre@scilifelab.se

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    Karlsson Hedestam group

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