SciLifeLab
Browse

File(s) not publicly available

Reason: It is human data.

Activating mutations remodeled the chromatin accessibility landscape to drive distinct regulatory networks in KMT2A-rearranged acute leukemia associated with immune evasion

dataset
posted on 2023-11-24, 07:04 authored by Qirui Zhang, Ton Falqués-Costa, Mattias PilhedenMattias Pilheden, Helena Sturesson, Anders Castor, Hanne V. Marquart, Birgitte Lausen, Axel Hyrenius Wittsten, Anna Hagström Andersson

This dataset includes ATAC-seq (Assay for Transposase-Accessible Chromatin using sequencing) of five infants with acute lymphoblastic leukemia. All patients had an underlying rearrangement of the KMT2A genes, either KMT2A::MLLT1 (n=1), KMT2A::AFF1 (n=3), or KMT2A::MLLT10 (n=1). Three patients also had activating mutations of NRAS G13D and/or KRAS G12D. The median age of the cohort was 2 months 7 days. Diagnostic sample from bone marrow underwent the ATAC-seq library preparation and sequenced on the NextSeq 500 platform (Illumina, San Diego, CA, USA).

Funding

The Swedish Cancer Society 20 1036

The Swedish Childhood Cancer Fund PR2021-0046

Governmental Funding of Clinical Research within the National Health Service

The molecular pathogenesis of KMT2A-rearranged leukemia from infancy to adulthood and the clinical impact of tumor heterogeneity

Swedish Research Council

Find out more...

History

Publisher

Lund University

Access request email

anna.hagstrom@med.lu.se

Usage metrics

    Anna Hagström Andersson research group

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC